A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes.
نویسندگان
چکیده
A novel method of enantioselective 1,3-dioxane construction via a hemiacetalization/intramolecular oxy-Michael addition cascade by a chiral phosphoric acid catalyst was developed. The product was successfully transformed into an optically active 1,3-polyol motif, indicating that the proposed reaction can provide useful chiral building blocks for the de novo synthesis of polyketides.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 58 شماره
صفحات -
تاریخ انتشار 2015